Tellurium is a Python-based environment for model building, simulation, and analysis of biochemical networks. It supports various modeling formats like SBML, Antimony, and CellML, allowing users to create and simulate complex biological systems. Tellurium integrates with libRoadRunner for efficient simulations and provides tools for parameter scanning, steady-state analysis, and stochastic simulations. Its capabilities include advanced plotting, SED-ML support for reproducible simulations, and COMBINE archive handling for model exchange. Tellurium is targeted towards researchers and students in systems biology and related fields who need a comprehensive platform for simulating and analyzing biological models.