STRING

Overview

STRING (Search Tool for Recurring Instances of Neighbouring Genes) is a comprehensive database designed for exploring protein-protein interaction networks. It integrates known and predicted interactions, leveraging direct (physical) and indirect (functional) associations. The database incorporates experimental data, computational prediction methods, and public text collections. STRING provides a user-friendly interface for searching proteins by name, sequence, or identifier and allows users to visualize networks, perform functional enrichment analysis, and download data for further analysis. Its value proposition lies in offering a consolidated platform for understanding protein relationships, aiding in drug target identification, pathway analysis, and elucidating complex biological processes. Use cases span academic research, pharmaceutical development, and systems biology.

Common tasks

Protein-Protein Interaction Analysis Functional Enrichment Analysis Network Visualization

FAQ

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What is STRING?

STRING is a database of known and predicted protein-protein interactions. The interactions include direct (physical) and indirect (functional) associations, which are derived from experimental data, computational prediction methods and public text collections.

How can I search for protein interactions?

You can search by protein name, multiple proteins, protein sequences, proteins with values/ranks, and protein families. You can also search by pathway/process/disease.

What organisms are covered in STRING?

STRING covers 12535 organisms, containing 59.3 mio proteins and >20 bln interactions (as of version 12.0).

Is there an API for STRING?

Yes, STRING provides a REST API that allows programmatic access to the database. This API can be used to resolve and map identifiers, and to fetch networks and other data items in various formats.

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